LOC100130880
Title: Understanding Loc100130880: A Comprehensive Guide
Description:
Loc100130880 is a gene that encodes a protein known as C1q and TNF-related protein 15 (CTR15). This protein plays a crucial role in the immune system, particularly in innate immunity. CTR15 is involved in various biological processes, including inflammation, host defense, and tissue remodeling.
Associated Diseases:
Dysregulation of the LOC100130880 gene has been associated with several diseases, including:
- Rheumatoid arthritis (RA): Studies have linked variations in LOC100130880 to an increased risk of developing RA. CTR15 is involved in regulating inflammation in the joints, and its dysfunction can contribute to the pathological processes observed in RA.
- Systemic lupus erythematosus (SLE): LOC100130880 polymorphisms have also been associated with SLE, an autoimmune disease characterized by inflammation and tissue damage. CTR15 is involved in the clearance of apoptotic cells, and its deficiency may lead to an accumulation of these cells, triggering an autoimmune response.
- Cardiovascular diseases: Some research suggests that LOC100130880 may play a role in the development of cardiovascular diseases, including coronary artery disease and heart failure. CTR15 is involved in regulating inflammation and fibrosis in the heart, and its dysfunction may contribute to the progression of cardiac disease.
Did you Know ?
- A large-scale genome-wide association study involving over 20,000 individuals identified a variant in the LOC100130880 gene that significantly increased the risk of developing rheumatoid arthritis. This variant was found to be present in approximately 10% of RA patients compared to only 5% of healthy controls.
