LMO2
Description
The LMO2 (LIM domain only 2) is a protein-coding gene located on chromosome 11.
LMO2, also known as Rhombotin-like 1, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein encoded by the LMO2 gene. LMO2 is a cysteine-rich protein with two LIM domains and is crucial for yolk sac erythropoiesis. It plays a vital role in hematopoietic development and is highly conserved. Aberrant LMO2 expression is a significant hallmark of T cell acute lymphoblastic leukemia. Several mechanisms contribute to its activation, including translocations near the 11p13 T-cell translocation cluster, mutations in an upstream noncoding DNA element that creates an aberrant enhancer, and recurrent mutations in LMO2 intron 1 leading to its overexpression. These mutations introduce new transcription factor binding sites, driving LMO2 expression.
LMO2 is also known as LMO-2, RBTN2, RBTNL1, RHOM2, TTG2.
