LINC01135
linc01135: A Long Non-Coding RNA with Diverse Roles in Health and Disease
Description
linc01135 is a long non-coding RNA (lncRNA) that plays a crucial role in regulating gene expression and various cellular processes. It is located on chromosome 1p36.11 and spans approximately 1,700 nucleotides. linc01135 is transcribed from a single exon and lacks a protein-coding function. Instead, it exerts its effects by interacting with other RNA molecules, proteins, and chromatin modifiers.
Associated Diseases
linc01135 has been implicated in the development and progression of several diseases, including:
- Cancer: Overexpression of linc01135 has been observed in various cancers, including breast cancer, lung cancer, and colorectal cancer. It promotes cancer cell proliferation, invasion, and metastasis by regulating key signaling pathways.
- Neurodegenerative disorders: Reduced levels of linc01135 have been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It plays a role in neuronal survival, differentiation, and synaptic plasticity.
- Cardiovascular diseases: Dysregulation of linc01135 has been associated with cardiovascular diseases such as heart failure and atherosclerosis. It affects vascular smooth muscle cell proliferation and migration, contributing to the development of cardiovascular complications.
- Immune disorders: linc01135 modulates immune responses by regulating the expression of immune-related genes. Alterations in its expression have been implicated in inflammatory diseases and autoimmune disorders.
Did you Know ?
According to a recent study published in the journal "Nature Medicine," high levels of linc01135 in breast cancer patients were associated with a significantly increased risk of metastasis and decreased overall survival. The study suggests that linc01135 could serve as a potential prognostic biomarker for breast cancer patients.
