LINC00982
Exploring the Role of linc00982 in Human Health
Description
linc00982, also known as long intergenic non-coding RNA 982, is a non-coding RNA molecule that plays a crucial role in various cellular processes. Non-coding RNAs, unlike messenger RNAs (mRNAs), do not code for proteins but rather regulate gene expression and other biological functions.
linc00982 is located on chromosome 8 in humans and is expressed in a wide range of tissues and cell types. It has been implicated in various cellular processes, including:
- Cell proliferation and differentiation: linc00982 promotes cell growth and division while inhibiting differentiation, suggesting its involvement in cancer development.
- Apoptosis: linc00982 regulates programmed cell death by inhibiting apoptosis, contributing to the survival of cancer cells.
- Epigenetic regulation: linc00982 interacts with DNA methylation modifiers and histone deacetylases to alter gene expression without changing the DNA sequence.
Associated Diseases
Research has linked linc00982 to several diseases, including:
- Cancer: Dysregulated expression of linc00982 has been associated with various cancers, including thyroid, breast, liver, and lung cancer.
- Neurodegenerative diseases: linc00982 may contribute to the development of Alzheimer's disease and Parkinson's disease by promoting neuronal cell death and neuroinflammation.
- Cardiovascular diseases: linc00982 has been implicated in the progression of atherosclerosis, a major risk factor for heart attacks and strokes.
Did you Know ?
- A study published in the journal "Cancer Research" found that high levels of linc00982 expression in thyroid cancer patients were associated with a decreased survival rate, highlighting its potential as a prognostic biomarker.
