LINC00935
LINC00935: A Long Non-Coding RNA with Diverse Roles in Health and Disease
Description:
LINC00935 is a long non-coding RNA (lncRNA) that plays a crucial role in regulating cellular processes. LncRNAs are transcripts of the human genome that do not code for proteins, but instead interact with DNA, RNA, and proteins to influence gene expression and cellular behavior.
LINC00935 is highly conserved across species, indicating its essential role in biological processes. It is primarily localized in the nucleus, where it interacts with chromatin-modifying proteins to regulate gene transcription.
Associated Diseases:
Alterations in LINC00935 expression have been implicated in a wide range of human diseases, including:
- Cancer: LINC00935 acts as an oncogene or tumor suppressor depending on the cancer type. It has been associated with the development and progression of breast, liver, lung, and colorectal cancers.
- Cardiovascular disease: LINC00935 regulates the expression of genes involved in heart function. Its dysregulation can contribute to heart failure, myocardial infarction, and arrhythmias.
- Neurodegenerative disorders: LINC00935 has been linked to Alzheimer's disease and Parkinson's disease. It may play a role in the accumulation of amyloid plaques and neuron loss in these conditions.
- Metabolic disorders: LINC00935 influences glucose and lipid metabolism. It has been associated with type 2 diabetes and obesity.
Did you Know ?
According to the Gene Expression Omnibus (GEO) database, LINC00935 is differentially expressed in over 20% of tumor samples compared to normal tissues. This suggests its significant role in cancer development and progression.
