LINC00883
linc00883: An Emerging Long Non-Coding RNA in Health and Disease
Description
Long non-coding RNAs (lncRNAs) are a class of RNA molecules that do not code for proteins. They are transcribed from the genome but do not undergo translation into proteins. LncRNAs are involved in various biological processes, including gene regulation, chromatin remodeling, and cellular differentiation.
linc00883 is a lncRNA located on chromosome 14q11.2. It is approximately 1.2 kilobases in length and has a highly conserved sequence across species. linc00883 is expressed in various tissues and cell types, including the liver, brain, and heart.
Associated Diseases
Recent research has implicated linc00883 in the development of several diseases. These include:
- Hepatocellular carcinoma (HCC): linc00883 is overexpressed in HCC and promotes tumor growth and metastasis.
- Glioma: linc00883 is upregulated in glioma and contributes to tumor proliferation and invasiveness.
- Myocardial infarction (MI): linc00883 is downregulated in MI and protects against cardiac injury.
Did you Know ?
Approximately 70% of the human genome is transcribed into non-coding RNAs, including lncRNAs. This highlights the importance of non-coding RNAs in cellular processes and disease development.
