LINC00684
Title: LINC00684: A Long Non-Coding RNA with Emerging Roles in Disease and Biology
Description:
LINC00684 is a long non-coding RNA (lncRNA) that has recently gained attention for its diverse biological functions and implications in various diseases. Unlike protein-coding genes, lncRNAs do not encode proteins but play crucial regulatory roles in gene expression, cellular processes, and disease pathogenesis. LINC00684 is located on chromosome 19p13.11 and spans approximately 850 nucleotides.
Associated Diseases:
Dysregulation of LINC00684 expression has been linked to a range of diseases, including:
- Cancer: LINC00684 overexpression has been observed in several types of cancer, including lung cancer, breast cancer, and hepatocellular carcinoma. It promotes tumor growth, metastasis, and resistance to therapy.
- Neurological disorders: LINC00684 has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. It affects neuron survival, synaptic plasticity, and cognitive function.
- Cardiovascular diseases: LINC00684 is involved in the regulation of cardiac function and vascular remodeling. Dysregulation of LINC00684 can contribute to hypertension, myocardial infarction, and heart failure.
- Immune disorders: LINC00684 plays a role in immune cell development and function. Its dysregulation has been associated with autoimmune diseases such as lupus and rheumatoid arthritis.
Did you Know ?
In patients with lung cancer, overexpression of LINC00684 was found in 65% of cases. It was associated with a significantly shorter overall survival and disease-free survival.
