LINC00638
linc00638: A Novel Long Non-Coding RNA with Implications in Disease and Beyond
Description
Long non-coding RNAs (lncRNAs) are a class of RNA molecules that are greater than 200 nucleotides in length but do not code for proteins. They have been found to play important roles in various cellular processes and are implicated in the development of numerous diseases.
linc00638 is a recently discovered lncRNA located on chromosome 1q44 in humans. It is approximately 2,800 nucleotides in length and is transcribed in the sense orientation. linc00638 exhibits tissue-specific expression, with highest levels found in the brain, heart, and skeletal muscle.
Associated Diseases
Research has linked linc00638 to several diseases, including:
- Breast cancer: linc00638 is overexpressed in breast cancer cells and is associated with increased cell proliferation, invasion, and metastasis.
- Glioma: Linc00638 is downregulated in glioma cells and its expression is correlated with better survival outcomes.
- Hepatocellular carcinoma: Linc00638 is overexpressed in hepatocellular carcinoma and promotes tumor growth and angiogenesis.
- Cardiovascular diseases: Linc00638 has been implicated in the development of atherosclerosis and heart failure.
Did you Know ?
A study by Xu et al. (2019) found that linc00638 expression was significantly lower in patients with coronary artery disease (CAD) compared to healthy controls. Moreover, linc00638 expression was inversely correlated with the severity of CAD.
