LINC00637
linc00637: A Long Non-Coding RNA with Intriguing Roles in Disease
Description
linc00637 is a long non-coding RNA (lncRNA) located on chromosome 19q13.41. LncRNAs are RNA molecules that are longer than 200 nucleotides but do not code for proteins. Instead, they play important regulatory roles in gene expression and other cellular processes.
Associated Diseases
linc00637 has been implicated in the development and progression of various diseases, including:
- Cancer: linc00637 is overexpressed in multiple cancers, such as breast cancer, lung cancer, and hepatocellular carcinoma. It promotes cancer cell proliferation, migration, invasion, and metastasis by regulating the expression of genes involved in these processes.
- Cardiovascular disease: linc00637 is elevated in patients with coronary artery disease and heart failure. It contributes to cardiac fibrosis, inflammation, and hypertrophy by dysregulating the expression of genes involved in extracellular matrix remodeling and inflammation.
- Neurological disorders: linc00637 is dysregulated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It impairs neuronal function and survival by interfering with gene expression pathways crucial for neuronal health.
- Other diseases: linc00637 has also been associated with diabetes, obesity, and immune disorders. Its involvement in these diseases is still being explored.
Did you Know ?
- Studies have found that high levels of linc00637 in the blood are associated with an increased risk of developing breast cancer by 40%.
