LINC00599
linc00599: A Long Non-Coding RNA with Diverse Roles in Health and Disease
Description
linc00599 is a long non-coding RNA (lncRNA) that plays a crucial role in various biological processes. It is located on chromosome 11q13.1 and is transcribed into a 2.5-kb RNA molecule. linc00599 does not code for proteins but regulates gene expression by interacting with other molecules, particularly microRNAs (miRNAs).
Associated Diseases
Dysregulation of linc00599 has been linked to several diseases, including:
- Cancer: Upregulation of linc00599 has been observed in various cancers, such as gastric cancer, liver cancer, and lung cancer. It promotes tumorigenesis by regulating cell proliferation, migration, and apoptosis.
- Cardiovascular diseases: linc00599 is involved in regulating blood pressure, heart rate, and endothelial function. Its dysregulation has been associated with hypertension and coronary artery disease.
- Immune disorders: linc00599 plays a role in immune cell differentiation and activation. Its alterations have been linked to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Did you Know ?
A study involving over 500 cancer patients found that high levels of linc00599 in tumor tissue were significantly associated with a poorer prognosis and shorter survival rates.
