LINC00346
LINC00346: An Intriguing Long Non-Coding RNA Linked to Disease
Description
LINC00346 is a long non-coding RNA (lncRNA) that plays a crucial role in various biological processes. LncRNAs are a class of RNA molecules that are longer than 200 nucleotides but do not code for proteins. They have been increasingly recognized for their regulatory roles in gene expression, cellular development, and disease progression.
LINC00346 is located on chromosome 11q13.1 and comprises four exons. It is highly expressed in several tissues, including the brain, heart, and liver. Studies have shown that LINC00346 is involved in regulating gene expression, cell proliferation, differentiation, and apoptosis.
Associated Diseases
Aberrant expression of LINC00346 has been linked to the development of several diseases, including:
- Cancer: LINC00346 has been found to be overexpressed in various types of cancer, such as breast cancer, lung cancer, and liver cancer. Its overexpression is associated with increased cell proliferation, invasion, and metastasis.
- Neurological disorders: LINC00346 dysregulation has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Studies suggest that reduced LINC00346 expression may contribute to neuronal damage and cognitive decline.
- Cardiovascular diseases: LINC00346 is involved in regulating cardiac function and development. Its dysregulation has been linked to heart failure and cardiomyopathy.
- Metabolic disorders: LINC00346 plays a role in glucose and lipid metabolism. Its altered expression has been associated with obesity, insulin resistance, and type 2 diabetes.
Did you Know ?
LINC00346 is one of the most extensively studied lncRNAs in cancer research. A recent study involving over 500 breast cancer patients revealed that high LINC00346 expression was associated with a significantly worse prognosis. Patients with high LINC00346 levels had lower survival rates and a higher risk of disease recurrence.
