LINC00282
linC00282: An Emerging Star in Cancer and Immune Regulation
Description
LinC00282 is a long non-coding RNA (lncRNA) molecule that plays a complex and dynamic role in various biological processes, including cell cycle regulation, cell differentiation, and immune response. It is transcribed from the human chromosome 7 and exhibits tissue-specific expression patterns, with high abundance in immune cells and certain tumor types.
Associated Diseases
Aberrant expression of linC00282 has been implicated in the development and progression of several diseases, particularly cancer. It has been identified as a potential biomarker and therapeutic target in various malignancies, including:
- Lung cancer: LinC00282 overexpression promotes tumor cell proliferation, invasion, and metastasis, and is associated with poor patient prognosis.
- Breast cancer: LinC00282 inhibits tumor cell growth and metastasis by regulating the expression of key genes involved in cell cycle control.
- Liver cancer: LinC00282 acts as a tumor suppressor and prevents liver cell carcinoma development by controlling cell proliferation and apoptosis.
- Colorectal cancer: LinC00282 overexpression promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway.
- Immune disorders: LinC00282 is involved in regulating immune responses and has been linked to autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis.
Did you Know ?
In a study of lung cancer patients, high linC00282 expression was found to be associated with a significantly shorter overall survival compared to patients with low expression. The median survival time was 30 months for patients with high linC00282 expression versus 60 months for those with low expression.
