LINC00176
linc00176: A Long Non-Coding RNA with Complex Roles in Disease
Description
linc00176 is a long non-coding RNA (lncRNA) that plays various roles in cellular regulation and disease development. lncRNAs are molecules that do not code for proteins but regulate gene expression and influence cellular processes. linc00176 is located on chromosome 11q13.1 and spans around 2.2 kilobases. It has been found to be differentially expressed in various types of cancer and other diseases.
Associated Diseases
linc00176 has been implicated in the pathogenesis of several diseases, including:
- Cancer: linc00176 has been found to be overexpressed in various cancers, including breast cancer, lung cancer, and hepatocellular carcinoma. It promotes cancer cell proliferation, invasion, and metastasis by regulating key signaling pathways.
- Cardiovascular Disease: linc00176 is associated with cardiovascular diseases such as atherosclerosis and coronary artery disease. It modulates the expression of genes involved in vascular inflammation and plaque formation.
- Neurodegenerative Disorders: linc00176 has been linked to neurodegenerative disorders such as Alzheimer's disease. It affects neuronal function and contributes to memory impairment and cognitive decline.
- Immune Disorders: linc00176 is involved in regulating immune responses. Dysregulation of linc00176 has been associated with autoimmune diseases and inflammatory conditions.
Did you Know ?
A recent study found that linc00176 expression was significantly elevated in patients with triple-negative breast cancer, a particularly aggressive type of breast cancer. Patients with high linc00176 levels had a significantly worse prognosis and shorter survival rates compared to those with low linc00176 expression.
