LIN7B
Description
The LIN7B (lin-7 homolog B, crumbs cell polarity complex component) is a protein-coding gene located on chromosome 19.
LIN7B is a protein encoded by the LIN7B gene in humans. It interacts with various proteins including ACCN3, GRIN2B, KCNJ12, and KCNJ4.
LIN7B plays a key role in the precise arrangement of channels and receptors within the cell membrane, especially in polarized cells. It forms complexes with other proteins to regulate the transport and recycling of these molecules to their correct locations. One important complex includes LIN7B, CASK, and APBA1, which binds to the motor protein KIF17 to move vesicles containing the NMDA receptor subunit NR2B along microtubules. This complex might link synaptic vesicle release with cell adhesion in the brain. LIN7B also ensures the proper placement of GRIN2B (a part of the NMDA receptor) at synapses and may help position synaptic vesicles there, guided by beta-catenin and cadherin. In epithelial cells, LIN7B is essential for directing Kir2 channels, the GABA transporter (SLC6A12), and the EGFR/ERBB family of receptors to the basolateral membrane. LIN7B might also increase the strength of ASIC3 acid-evoked currents by stabilizing the channel on the cell surface.
LIN7B is also known as LIN-7B, MALS-2, MALS2, VELI2.
