LIN7A
Description
The LIN7A (lin-7 homolog A, crumbs cell polarity complex component) is a protein-coding gene located on chromosome 12.
LIN7A is a protein encoded by the LIN7A gene in humans. It interacts with several other proteins, including CASK, DLG1, and KCNJ12.
LIN7A plays a crucial role in organizing the distribution of channels and receptors within the cell membrane, particularly in polarized cells. It forms complex structures with other proteins, regulating the delivery and recycling of proteins to their specific locations within the cell. One notable complex includes LIN7A, CASK, and APBA1, which associates with the motor protein KIF17 to transport vesicles containing the NMDA receptor subunit NR2B along microtubules. This complex is potentially involved in linking synaptic vesicle release with cell adhesion in the brain. LIN7A ensures the correct positioning of the NMDA receptor subunit GRIN2B at neuronal synapses, potentially aiding in the localization of synaptic vesicles. Additionally, LIN7A directs Kir2 channels, the GABA transporter (SLC6A12), and EGFR/ERBB1, ERBB2, ERBB3, and ERBB4 to the basolateral membrane of epithelial cells.
LIN7A is also known as LIN-7A, LIN7, MALS-1, MALS1, TIP-33, VELI1.
