LIN28A
Description
The LIN28A (lin-28 homolog A) is a protein-coding gene located on chromosome 1.
LIN28A is a protein that regulates gene expression. It inhibits the processing of pre-let-7 miRNAs, which are involved in developmental timing and cell differentiation. LIN28A also regulates the translation of mRNAs involved in developmental timing, pluripotency, and metabolism.
LIN28A is an RNA-binding protein that plays a crucial role in regulating gene expression by controlling both microRNA (miRNA) processing and mRNA translation. It inhibits the processing of pre-let-7 miRNAs, a family of miRNAs involved in developmental timing and cell differentiation. This inhibition contributes to maintaining pluripotency in embryonic stem cells by preventing let-7-mediated differentiation. LIN28A also regulates the translation of mRNAs involved in developmental timing, pluripotency, and metabolism. It binds to specific mRNAs and enhances their translation, increasing the efficiency of protein synthesis. These target mRNAs include those encoding metabolic enzymes such as PFKP, PDHA1, and SDHA, which contribute to glycolysis and oxidative phosphorylation. Furthermore, LIN28A is involved in skeletal muscle differentiation through its regulation of IGF2 expression. It interacts with various proteins involved in RNA processing and translation, including TUT4, TUT7, DHX9, and EIF3S2.
LIN28A is also known as CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A.
Associated Diseases
- lysosomal storage disease
- cancer
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 48
- spermatogenic failure 1
