LIMS2
Description
The LIMS2 (LIM zinc finger domain containing 2) is a protein-coding gene located on chromosome 2.
LIM zinc finger domain containing 2 (LIMS2) is a protein encoded by the LIMS2 gene in humans. It belongs to a small family of focal adhesion proteins that interact with integrin-linked kinase (ILK), a protein involved in protein-protein interactions with the extracellular matrix. LIMS2 contains five LIM domains, each forming two zinc fingers, which mediate interactions that regulate cell shape and migration. A pseudogene of LIMS2 is located on chromosome 4, and multiple transcript variants encoding different isoforms have been identified.
LIMS2 acts as an adapter protein within the cytoplasm, linking beta-integrins to the actin cytoskeleton. It further bridges this complex to cell surface receptor tyrosine kinases and growth factor receptors, ultimately contributing to the regulation of cell spreading and migration.
LIMS2 is also known as LGMD2W, MDRCMTT, PINCH-2, PINCH2.
