LIMS1
Description
The LIMS1 (LIM zinc finger domain containing 1) is a protein-coding gene located on chromosome 2.
LIMS1, also known as PINCH1 and NY-REN-48, is a protein encoded by the LIMS1 gene in humans. It functions as an adaptor protein containing five LIM domains, which are double zinc fingers. LIMS1 likely participates in integrin signaling through its interaction with integrin-linked kinase (ILK) via its LIM domains, found in focal adhesion plaques. It is thought to act as a bridge between ILK and NCK2, an adaptor protein involved in growth factor receptor kinase signaling pathways. Its localization at the periphery of spreading cells suggests a role in integrin-mediated cell adhesion or spreading. LIMS1 has been shown to interact with both ILK and NCK2.
LIMS1 acts as a bridging protein within a cytoplasmic complex, connecting beta-integrins to the actin cytoskeleton. It also links this complex to cell surface receptor tyrosine kinases and growth factor receptors. This role suggests involvement in regulating cell survival, proliferation, and differentiation.
LIMS1 is also known as PINCH, PINCH-1, PINCH1.
