LILRA5
Description
The LILRA5 (leukocyte immunoglobulin like receptor A5) is a protein-coding gene located on chromosome 19.
LILRA5 (Leukocyte immunoglobulin-like receptor subfamily A member 5) is a protein encoded by the LILRA5 gene. This gene belongs to a cluster of leukocyte receptor genes on chromosome 19q13.4. LILRA5 has four known isoforms, and its function is not completely understood. However, it is highly similar to other LILR genes, suggesting that it may have similar activating and inhibitory roles in leukocytes. Studies have shown that crosslinking LILRA5 on monocytes triggers calcium flux and the release of pro-inflammatory cytokines, indicating its potential role in initiating innate immune responses. Recent research has linked genetic variations in LILRA5 to late-onset sporadic Alzheimer's disease (LOAD). While LILRA5's precise role in Alzheimer's is still under investigation, it may contribute to the disease through interactions with amyloid-beta.
LILRA5 is also known as CD85, CD85F, ILT-11, ILT11, LILRB7, LIR-9, LIR9.
Associated Diseases
- Alzheimer disease
- common variable immunodeficiency
- isolated agammaglobulinemia
- classic Hodgkin lymphoma
- severe combined immunodeficiency due to CARD11 deficiency
