LEUTX
Description
The LEUTX (leucine twenty homeobox) is a protein-coding gene located on chromosome 19.
Isoform 1 of LEUTX, also known as Leucine-twenty homeobox, is a paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). It may act as a regulator of embryo genome activation (PubMed:27578796). LEUTX binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355). {ECO:0000269|PubMed:27578796, ECO:0000269|PubMed:30479355}
LEUTX is also known as -.
Associated Diseases
- Bartsocas-Papas syndrome 1
- myeloid leukemia
- facioscapulohumeral muscular dystrophy
- cancer
- mixed neuronal-glial tumor
