LEF1
Description
The LEF1 (lymphoid enhancer binding factor 1) is a protein-coding gene located on chromosome 4.
Lymphoid enhancer-binding factor 1 (LEF1) is a protein encoded by the LEF1 gene in humans. It's part of the T cell factor/lymphoid enhancer factor (TCF/LEF) family. LEF1 is a 48-kD nuclear protein found in pre-B and T cells. It binds to a vital site in the T-cell receptor-alpha (TCRA) enhancer, maximizing enhancer activity. LEF1 is related to the high mobility group protein-1 (HMG1) family of regulatory proteins. High levels of LEF1 are linked to disease progression and poor outcomes in B-cell chronic lymphocytic leukemia and other cancers like colorectal cancer. LEF1 is a promising target for drug development. LEF1 has been shown to interact with ALX4, AML-1, Catenin beta-1/β-catenin/CTNNB1, EP300, MITF, PIAS4, SMAD2, and SMAD3.
LEF1 is a transcription factor that binds to specific DNA sequences, playing a role in the Wnt signaling pathway. It activates gene expression in the presence of CTNNB1 and EP300. LEF1's activity can be antagonized by PIAG and repressed by TLE1, TLE2, TLE3, and TLE4. LEF1 regulates T-cell receptor alpha enhancer function, is essential for the development of IL17A-expressing gamma-delta T cells, and positively regulates odontoblast differentiation. It may also be involved in hair cell differentiation and follicle morphogenesis.
LEF1 is also known as LEF-1, TCF10, TCF1ALPHA, TCF7L3.
Associated Diseases
- split hand-foot malformation
- pancreatic ductal adenocarcinoma
- sebaceous adenoma
- carcinoma of liver and intrahepatic biliary tract
