LDHC
Description
The LDHC (lactate dehydrogenase C) is a protein-coding gene located on chromosome 11.
Lactate dehydrogenase (LDH or LD) is an enzyme found in nearly all living cells. It catalyzes the conversion of pyruvate to lactate and back, as it converts NAD+ to NADH and back. A dehydrogenase is an enzyme that transfers a hydride from one molecule to another. LDH exists in four distinct enzyme classes. This article is specifically about the NAD(P)-dependent L-lactate dehydrogenase. Other LDHs act on D-lactate and/or are dependent on cytochrome c: D-lactate dehydrogenase (cytochrome) and L-lactate dehydrogenase (cytochrome). LDH is expressed extensively in body tissues, such as blood cells and heart muscle. Because it is released during tissue damage, it is a marker of common injuries and disease such as heart failure.
== Reaction ==
Lactate dehydrogenase catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate, the final product of glycolysis, to lactate when oxygen is absent or in short supply, and it performs the reverse reaction during the Cori cycle in the liver.
May play a role in sperm motility.
LDHC is also known as CT32, LDH3, LDHX.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 3
- spermatogenic failure 7
- spermatogenic failure 29
- spermatogenic failure 49
- spermatogenic failure 45
- spermatogenic failure 43
- spermatogenic failure 19
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 70
- spermatogenic failure 47
- spermatogenic failure 27
- spermatogenic failure 46
- spermatogenic failure 18
- spermatogenic failure 41
