LCOR
Description
The LCOR (ligand dependent nuclear receptor corepressor) is a protein-coding gene located on chromosome 10.
LCOR (Ligand-dependent corepressor) is a protein encoded by the LCOR gene in humans. It serves as a transcriptional corepressor, widely expressed in both fetal and adult tissues. LCOR binds to activated nuclear receptors through a specific LxxLL motif, also known as a nuclear receptor (NR) box.
LCOR can act as a transcription activator, binding to DNA sequences with the pattern 5'-CCCTATCGATCGATCTCTACCT-3'. However, its primary role is as a repressor, inhibiting the activation of transcription by various nuclear receptors. These receptors include ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA, and VDR.
LCOR is also known as C10orf12, MLR2.
Associated Diseases
- prostate cancer
- breast cancer
- cervical intraepithelial neoplasia
- cervical squamous intraepithelial neoplasia
