LAMTOR3
Description
The LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3) is a protein-coding gene located on chromosome 4.
MAPKSP1 is a scaffold protein encoded by the MAPKSP1 gene. It interacts with MAP kinase kinase MAP2K1/MEK1 and MAP kinase MAPK2/ERK1. MAPKSP1 enhances the activation of MAPK2 and is believed to function as an adaptor to increase the efficiency of the MAP kinase cascade.
LAMTOR3, also known as Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mitogen-activated protein kinase kinase 1-interacting protein 1, or Mitogen-activated protein kinase scaffold protein 1, is part of the Ragulator complex. It plays a crucial role in sensing amino acid levels and activating mTORC1, a signaling complex that promotes cell growth in response to various stimuli, including growth factors, energy levels, and amino acids. This activation is triggered by amino acids via a mechanism involving the lysosomal V-ATPase. The Ragulator complex acts as a guanine nucleotide exchange factor (GEF) for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC, and/or RagD/RRAGD), activating them. It also mediates the recruitment of these activated Rag GTPases to the lysosome membrane. The activated Ragulator and Rag GTPases work together to recruit mTORC1 to the lysosomes, where it is subsequently activated. Furthermore, LAMTOR3 is an adaptor protein that enhances the efficiency of the MAP kinase cascade, facilitating the activation of MAPK2.
LAMTOR3 is also known as MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3.
Associated Diseases
- Alzheimer disease
- multiple sclerosis
- Parkinson disease
- lysosomal storage disease
- familial atrial fibrillation
- Brugada syndrome
