KRT19
Description
The KRT19 (keratin 19) is a protein-coding gene located on chromosome 17.
Keratin-19, also known as cytokeratin-19 (CK-19), is a 40 kDa protein encoded by the KRT19 gene. It is a type I keratin involved in the structural integrity of epithelial cells. Unlike other keratins, it is not paired with a basic cytokeratin but is specifically found in the embryonic periderm, a temporary layer covering the developing epidermis. KRT19 is also known as Cyfra 21-1 and is a highly sensitive marker for detecting tumor cells in various tissues, including lymph nodes, blood, and bone marrow, particularly in breast cancer patients.
KRT19 plays a role in organizing myofibers in striated muscle. It collaborates with KRT8 to connect the contractile apparatus to dystrophin at the costameres, specialized structures that link the muscle cytoskeleton to the extracellular matrix.
KRT19 is also known as CK19, K19, K1CS.
Associated Diseases
- esophageal cancer
- hereditary breast ovarian cancer syndrome
- cancer
- breast cancer
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 20
- spermatogenic failure 72
- spermatogenic failure 51
- spermatogenic failure 27
- spermatogenic failure 46
- spermatogenic failure 18
- spermatogenic failure 5
- spermatogenic failure 24
