KLK5
Description
The KLK5 (kallikrein related peptidase 5) is a protein-coding gene located on chromosome 19.
Kallikrein-5, previously known as stratum corneum tryptic enzyme (SCTE), is a serine protease produced in the epidermis. In humans, it is coded by the KLK5 gene. This gene is one of fifteen kallikrein subfamily members grouped together on chromosome 19. Its production is increased by estrogens and progestins. Alternative splicing creates different versions of the gene's instructions, but they all code for the same protein. KLK5 has been suggested to regulate cell shedding (desquamation) in cooperation with KLK7 and KLK14, due to its ability to break down proteins that form the connections between cells in the outer layer of skin. It's thought that KLK5 controls this process because it can activate itself and also activate KLK7 and KLK14.
KLK5 is also known as KLK-L2, KLKL2, SCTE.
Associated Diseases
- urinary bladder cancer
- endometrial cancer
- breast cancer
- type 2 diabetes mellitus
- retinitis pigmentosa and erythrocytic microcytosis
- aceruloplasminemia
- hemoglobin D disease
- abetalipoproteinemia
- Liberfarb syndrome
- autosomal dominant Kenny-Caffey syndrome
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- X-linked retinoschisis
