KLF9
Description
The KLF9 (KLF transcription factor 9) is a protein-coding gene located on chromosome 9.
KLF9 is a protein encoded by the KLF9 gene in humans. It belongs to the Sp1 C2H2-type zinc finger family of transcription factors. Studies have shown KLF9 regulates animal development, including cell differentiation of B cells, keratinocytes, and neurons. It is also a key transcriptional regulator for uterine endometrial cell proliferation, adhesion, and differentiation, essential during pregnancy and turned off during tumorigenesis. KLF9 binds to GC box elements in promoters. Binding to a single GC box inhibits mRNA expression, while binding to tandemly repeated GC boxes activates transcription. Oxidative stress increases KLF9 expression, making the cell more sensitive to oxidative stress and reactive oxygen species (ROS). Overexpression of KLF9 sensitizes the cell to oxidative stress and ROS, while silencing its expression provides resistance to oxidative stress and ROS-related cell death. KLF9 is upregulated by ROS and promotes ROS-related cell death. It exhibits similarities to other known oxidative stress genes like NQO1 and HMOX1.
KLF9 is a transcription factor that binds to GC box promoter elements. It selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. KLF9 acts as an epidermal circadian transcription factor regulating keratinocyte proliferation.
KLF9 is also known as BTEB, BTEB1.
