KLF3
Description
The KLF3 (KLF transcription factor 3) is a protein-coding gene located on chromosome 4.
KLF3, also known as Basic Krüppel-like factor (BKLF), is a protein that regulates gene expression in humans. It belongs to the Krüppel-like factor family of transcription factors, which all contain three zinc fingers at their C-terminus that bind to DNA. These proteins recognize CACCC or CGCCC sequences in DNA. While the C-termini of different KLFs are similar, the N-termini vary, leading to different functions. KLF3 primarily acts as a repressor, turning genes off. It accomplishes this by associating with co-repressor proteins called CTBP1 and CTBP2. These co-repressors bind to a specific motif in the N-terminus of KLF3, and then recruit enzymes that modify histones, the proteins that package DNA, ultimately silencing gene expression.
KLF3 binds to the CACCC box of genes expressed in erythroid cells, suggesting its involvement in the production of red blood cells (hematopoiesis).
KLF3 is also known as BKLF.
