KLF2
Description
The KLF2 (KLF transcription factor 2) is a protein-coding gene located on chromosome 19.
KLF2, also known as Lung Krüppel-like Factor (LKLF), is a protein encoded by the KLF2 gene on chromosome 19. It belongs to the Krüppel-like factor family of zinc finger transcription factors and is involved in various biological processes, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.
The discovery of KLF2 stemmed from the identification of Erythroid Krüppel-like Factor (EKLF or KLF1), which is crucial for embryonic erythropoiesis. KLF1 promotes the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) by binding to conserved CACCC domains. KLF2, initially named for its high expression in the adult mouse lung, was identified in 1995.
The defining feature of the KLF family is the presence of three conserved Cysteine2/Histidine2 zinc fingers located at the C-terminus of the protein.
KLF2 is also known as LKLF.
