KLF13
Description
The KLF13 (KLF transcription factor 13) is a protein-coding gene located on chromosome 15.
KLF13, also known as Kruppel-like factor 13, is a protein encoded by the KLF13 gene in humans. There is some evidence suggesting KLF13 plays a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been linked to obesity and orexigenic processes. Ghrelin levels also showed a positive correlation with methylation levels of cg07814318. Furthermore, expression levels of KLF13 were observed to be decreased in the brains of starved mice and increased in obese mice. KLF13 belongs to a family of transcription factors containing 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes. KLF13 was initially identified as the RANTES factor of late activated T lymphocytes (RFLAT)-1. It regulates the expression of the chemokine RANTES in T lymphocytes. It serves as a lynchpin, inducing a large enhancesome.
KLF13 is also known as BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1.
