KIN
Description
The KIN (Kin17 DNA and RNA binding protein) is a protein-coding gene located on chromosome 10.
KIN usually refers to kinship and family.
KIN is involved in DNA replication and the cellular response to DNA damage. It may participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. KIN may play a role in illegitimate recombination and regulation of gene expression. It may also participate in mRNA processing. KIN binds to double-stranded DNA in vitro and preferentially to curved DNA in vitro and in vivo. It binds to RNA in vitro via its C-terminal domain.
KIN is also known as BTCD, KIN17, Rts2.
Associated Diseases
- lysosomal storage disease
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- breast cancer
- Brugada syndrome
- familial atrial fibrillation
- ventricular fibrillation, paroxysmal familial, type 1
- cardiomyopathy, dilated, 2I
- familial sick sinus syndrome
- arrhythmogenic right ventricular dysplasia 1
