KIF26A
Description
The KIF26A (kinesin family member 26A) is a protein-coding gene located on chromosome 14.
KIF26A, also known as kinesin-11, is a human protein encoded by the KIF26A gene. It is a member of the kinesin family of motor proteins.
KIF26A, an atypical kinesin, plays a key role in the development of both the enteric and cerebral cortex nervous systems. In enteric neuron development, it acts as a repressor of a cell growth signaling pathway, potentially through its interaction with GRB2, which prevents GRB2 from binding to SHC and ultimately reduces GDNF-Ret signaling. KIF26A also binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity. In cerebral cortical development, KIF26A functions as a microtubule stabilizer, regulating neurite growth and radial migration of cortical excitatory neurons.
KIF26A is also known as CDCBM11.
