KIF13A
Description
The KIF13A (kinesin family member 13A) is a protein-coding gene located on chromosome 6.
KIF13A is a protein encoded by the KIF13A gene in humans. It has been shown to interact with AP1B1.
KIF13A is a plus end-directed microtubule-dependent motor protein that plays a crucial role in intracellular transport. It regulates various cellular processes including the transport of mannose-6-phosphate receptor (M6PR) to the plasma membrane, endosomal sorting during melanosome biogenesis, and cytokinesis. KIF13A facilitates the movement of M6PR-containing vesicles from the trans-Golgi network to the plasma membrane by interacting with the AP-1 complex. During melanosome maturation, KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by forming peripheral recycling endosomal subdomains in melanocytes. Additionally, KIF13A is required for the abscission step in cytokinesis, where it mediates the translocation of ZFYVE26, and possibly TTC19, to the midbody.
KIF13A is also known as RBKIN, bA500C11.2.
Associated Diseases
- low grade glioma
- ovarian cancer
- endometrial cancer
- urinary bladder cancer
- apraxia
- Chiari malformation
- cancer
- schizophrenia
