KIAA2026
KIAA2026: A Comprehensive Guide
Description
KIAA2026, also known as OTUD7B, is a protein that plays a crucial role in cellular processes. It belongs to the ovarian tumor domain (OTU) family of proteins, which are involved in various cellular functions, including ubiquitination and deubiquitination. KIAA2026 specifically functions as a deubiquitinase, removing ubiquitin chains from target proteins.
Associated Diseases
Dysfunction of KIAA2026 has been linked to several diseases, including:
- Parkinson's disease: KIAA2026 deficiency has been associated with the accumulation of aggregated proteins, known as Lewy bodies, which are a hallmark of Parkinson's disease.
- Amyotrophic lateral sclerosis (ALS): KIAA2026 mutations have been found in patients with ALS, a neurodegenerative disorder that affects motor neurons.
- Alzheimer's disease: Altered expression of KIAA2026 has been observed in Alzheimer's disease, suggesting its involvement in the underlying disease mechanisms.
- Cancers: KIAA2026 has been implicated in the development and progression of certain cancers, including breast cancer, lung cancer, and leukemia.
Did you Know ?
KIAA2026 is highly expressed in the brain, particularly in the hippocampus and cortex, which are crucial for memory and cognition. This suggests its involvement in these cognitive processes.
