KIAA1468
KIAA1468: An Emerging Player in Cancer and Neurodegenerative Diseases
Description
KIAA1468 is a protein encoded by the gene of the same name. It is located on chromosome 17q21.3 and consists of 451 amino acids. KIAA1468 is primarily expressed in the brain and testes, with lower levels found in other tissues.
The function of KIAA1468 is not fully understood, but it is believed to play a role in regulating cell growth, proliferation, and differentiation. It interacts with various proteins involved in cell cycle regulation, DNA repair, and signal transduction pathways.
Associated Diseases
KIAA1468 has been implicated in the development of several diseases, including:
- Cancer: KIAA1468 overexpression has been observed in various types of cancer, including lung, breast, colorectal, and pancreatic cancer. It promotes cancer cell proliferation, invasion, and metastasis.
- Neurodegenerative diseases: KIAA1468 levels are decreased in patients with Alzheimer's disease and Parkinson's disease. It may play a protective role in these diseases by preventing neuronal damage.
Did you Know ?
- In a study of lung cancer patients, increased KIAA1468 expression was associated with a 35% higher risk of metastasis.
