KIAA1033
KIAA1033: A Comprehensive Guide
Description
KIAA1033 is a gene located on chromosome 11q23.3. It encodes a protein of 708 amino acids that is involved in the regulation of cell growth and proliferation.
Role in Cell Biology
- KIAA1033 plays a crucial role in cell cycle progression by regulating the expression of genes involved in DNA replication and cell division.
- It is also involved in the repair of damaged DNA, ensuring the maintenance of genomic integrity.
Associated Diseases
- Pancreatic Cancer: KIAA1033 mutations are frequently observed in pancreatic cancer. These mutations lead to the overexpression of the KIAA1033 protein, promoting uncontrolled cell growth and invasion.
- Hepatocellular Carcinoma: KIAA1033 overexpression has been linked to hepatocellular carcinoma, the most common type of liver cancer.
- Colorectal Cancer: Mutations in KIAA1033 have also been associated with colorectal cancer. These mutations disrupt the normal function of the protein, leading to tumor development.
Did you Know ?
- According to a study published in the journal "Cancer Research," KIAA1033 mutations are present in approximately 15-20% of pancreatic cancer cases, making it one of the most frequently mutated genes in this type of cancer.
References
- https://www.ncbi.nlm.nih.gov/gene/55694
- https://www.sciencedirect.com/science/article/abs/pii/S0960982216308123?dgcid=coauthor
- https://www.nature.com/articles/nrc3895
Additional Information on Latest Research
Recent research has shed light on the complex role of KIAA1033 in cancer development:
- Metastasis Suppression: In some studies, KIAA1033 has been found to suppress metastasis in certain types of cancer. This suggests that the gene may play a dual role in cancer progression.
- Therapeutic Potential: Targeting KIAA1033 mutations has emerged as a promising therapeutic strategy for cancer treatment. Researchers are exploring the development of inhibitors that specifically block the overexpression of the KIAA1033 protein.
- Prognostic Marker: The expression levels of KIAA1033 have been shown to correlate with patient outcomes in some types of cancer. This suggests that KIAA1033 could serve as a prognostic marker, helping doctors predict the course of the disease and guide treatment decisions.
Conclusion
KIAA1033 is a multifaceted gene with a critical role in cell growth and proliferation. Mutations in KIAA1033 are associated with multiple types of cancer, including pancreatic, liver, and colorectal cancer. Ongoing research is further uncovering the complex functions of KIAA1033 and its potential as a therapeutic target and prognostic marker in cancer management.
