KDM7A
Description
The KDM7A (lysine demethylase 7A) is a protein-coding gene located on chromosome 7.
Lysine demethylase 7A is a protein that in humans is encoded by the KDM7A gene.
KDM7A is a histone demethylase that plays a crucial role in brain development. It specifically removes methyl groups from dimethylated Lys-9, Lys-27, and Lys-36 residues of histone H3 (H3K9me2, H3K27me2, H3K36me2, respectively), as well as monomethylated Lys-20 residue of histone H4 (H4K20Me1). This activity contributes to the regulation of gene expression through the histone code. KDM7A's activity is influenced by the presence of trimethylated Lys-4 of histone H3 (H3K4me3). When H3K4me3 is present, KDM7A loses its demethylase activity towards H3K9me2 but maintains high activity towards H3K27me2. Conversely, in the absence of H3K4me3, KDM7A can demethylate H3K9me2. KDM7A demonstrates activity towards H4K20Me1 only when nucleosomes are used as substrates, not when histone octamers are used.
KDM7A is also known as JHDM1D.
Associated Diseases
- cancer
- endometrial cancer
- urinary bladder carcinoma
- autosomal recessive spondylocostal dysostosis
- Prata-Liberal-Goncalves syndrome
- osteomesopyknosis
- primary basilar invagination
- breast cancer
