KCTD8
Description
The KCTD8 (potassium channel tetramerization domain containing 8) is a protein-coding gene located on chromosome 4.
The KCTD8 gene in humans codes for a protein called Potassium channel tetramerization domain containing 8. This protein plays a role in cellular processes and is associated with various functions.
KCTD8 acts as an auxiliary subunit of GABA-B receptors, influencing the receptor's response in terms of drug action (pharmacology) and the speed of its activation and deactivation (kinetics). It enhances the effectiveness of agonists, the molecules that activate the receptor, and significantly alters how the receptor interacts with G-proteins, the signaling molecules involved in cellular communication. Specifically, KCTD8 accelerates the onset of the receptor's response and promotes its desensitization, which is the process by which the receptor becomes less responsive to continued stimulation.
KCTD8 is also known as -.
