KCTD21
Description
The KCTD21 (potassium channel tetramerization domain containing 21) is a protein-coding gene located on chromosome 11.
KCTD21 acts as a substrate-specific adapter within the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. This complex is responsible for tagging target proteins with ubiquitin, marking them for degradation by the proteasome. KCTD21 specifically promotes the ubiquitination of HDAC1, a histone deacetylase. Furthermore, KCTD21 can antagonize the Hedgehog signaling pathway by hindering the nuclear translocation of GLI1, a transcription factor. This antagonism likely arises from KCTD21's downregulation of HDAC1, which keeps GLI1 acetylated and inactive. Research has shown that KCTD21 effectively suppresses cell growth and tumorigenicity in medulloblastoma (MDB).
KCTD21 is also known as KCASH2.
