KCNA5
Description
The KCNA5 (potassium voltage-gated channel subfamily A member 5) is a protein-coding gene located on chromosome 12.
KCNA5, also known as Kv1.5, is a protein encoded by the KCNA5 gene in humans. It belongs to the potassium channel, voltage-gated, shaker-related subfamily and is a delayed rectifier potassium channel. This gene is intronless and clustered with genes KCNA1 and KCNA6 on chromosome 12. Mutations in this gene have been associated with atrial fibrillation and sudden cardiac death. KCNA5 is involved in pulmonary vascular function, playing a role in setting the resting membrane potential and in hypoxic pulmonary vasoconstriction. KCNA5 interacts with DLG4, SAP97, and Actinin, alpha 2.
KCNA5 is a voltage-gated potassium channel responsible for potassium ion transport across excitable membranes. It forms tetrameric channels, allowing potassium ions to move according to their electrochemical gradient. The channel opens and closes in response to membrane voltage fluctuations. KCNA5 can form both homotetrameric channels composed of only KCNA5 subunits and heterotetrameric channels containing varying proportions of KCNA1, KCNA2, KCNA4, KCNA5, and potentially other family members. The specific alpha subunits within the channel determine its properties. Cytoplasmic beta subunits modulate channel function by regulating the location of alpha subunits and accelerating inactivation. Homotetrameric channels exhibit rapid activation and slow inactivation. KCNA5 might contribute to insulin secretion regulation in normal pancreatic islets. Isoform 2 displays a voltage-dependent recovery from inactivation and excessive cumulative inactivation.
KCNA5 is also known as ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1.
