JMY
Description
The JMY (junction mediating and regulatory protein, p53 cofactor) is a protein-coding gene located on chromosome 5.
JMY refers to the human gene encoding the Junction-mediating and -regulatory protein. This protein is a dual-function protein, acting as both a nuclear co-factor for the p53 tumor suppressor protein and a cytoplasmic regulator of actin dynamics.
JMY acts as a dual-function protein, depending on its cellular location. In the nucleus, JMY acts as a co-factor for the p53 tumor suppressor protein, enhancing p53's response to stress signals such as DNA damage. This function is mediated through its interaction with the p300/EP300 protein, resulting in increased p53-dependent transcription and ultimately apoptosis. In the cytoplasm, JMY functions as a regulator of actin dynamics, promoting both branched and unbranched actin filament formation. JMY activates the Arp2/3 complex to induce branched actin networks and can also catalyze actin polymerization independently, forming unbranched filaments. This role contributes to cell motility. During nutrient stress, JMY is recruited by MAP1LC3B to the phagophore membrane, where it promotes actin assembly during autophagy.
JMY is also known as WHAMM2, WHDC1L3.
