IRGC
Immune Response Gene Clusters (IRGC)
Description
Immune response gene clusters (IRGCs) are genomic regions containing multiple immune-related genes that are inherited together as a single unit. These clusters play a crucial role in coordinating the immune response, providing a rapid and efficient response to pathogens. IRGCs have been identified in various species, including humans, mice, and zebrafish.
Associated Diseases
Dysregulation of IRGCs has been linked to several immune disorders, including:
- Autoimmune diseases: Such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis, where the immune system mistakenly attacks the body's own tissues.
- Immunodeficiencies: Such as severe combined immunodeficiency (SCID), where the immune system is weakened or absent.
- Inflammatory diseases: Such as asthma, allergies, and Crohn's disease, where excessive inflammation leads to tissue damage.
- Cancer: IRGCs have been found to play a role in tumor development and progression, influencing immune surveillance and tumor cell growth.
Did you Know ?
- A study published in Nature Genetics found that individuals with certain variants in IRGCs have an increased risk of developing autoimmune diseases, suggesting a genetic link between IRGCs and immune dysfunction.
