IQGAP1
Description
The IQGAP1 (IQ motif containing GTPase activating protein 1) is a protein-coding gene located on chromosome 15.
IQGAP1 is a ubiquitously expressed scaffold protein involved in regulating various cellular processes including organization of the actin cytoskeleton, transcription, cell adhesion, and cell cycle regulation. It was originally thought to act as a GTPase activating protein (GAP) due to its RasGAP-related domain (GRD), but it was later discovered that IQGAP1 does not have GAP function. Instead, it binds to and stabilizes the active (GTP-bound) forms of RAC1 and CDC42. IQGAP1 is a therapeutic target due to its role in numerous signaling pathways implicated in cancer progression.
IQGAP1 plays a key role in regulating the dynamics and assembly of the actin cytoskeleton. It binds to activated CDC42 but does not stimulate its GTPase activity. IQGAP1 associates with calmodulin and may serve as an assembly scaffold for the organization of a multimolecular complex that interfaces incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. It has been suggested that IQGAP1 may promote neurite outgrowth and play a role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.
IQGAP1 is also known as HUMORFA01, SAR1, p195.
Associated Diseases
- cancer
- Noonan syndrome
- Costello syndrome
- allergic disease
- cardiofaciocutaneous syndrome
- thyroid gland adenocarcinoma
- asthma
