INTS6
Description
The INTS6 (integrator complex subunit 6) is a protein-coding gene located on chromosome 13.
INTS6, the gene encoding Integrator complex subunit 6, is a human gene that produces a DEAD box protein. DEAD box proteins are putative RNA helicases, characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif. The INTS6 protein is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in the 3' end processing of snRNAs. INTS6 is also considered a candidate tumor suppressor and is located in a region of the genome where loss of heterozygosity (LOH) is frequent. Three transcript variants have been identified for INTS6, encoding two different isoforms.
INTS6 is a component of the Integrator (INT) complex, which plays a role in the transcription and 3'-box-dependent processing of the small nuclear RNAs (snRNAs) U1 and U2. The INT complex interacts with the C-terminal domain (CTD) of RNA polymerase II's largest subunit (POLR2A) and is likely recruited to the U1 and U2 snRNA genes. INTS6 contributes to the recruitment of cytoplasmic dynein to the nuclear envelope, likely as part of the INT complex. INTS6 may act as a tumor suppressor, as its ectopic expression has been shown to inhibit tumor cell growth.
INTS6 is also known as DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2.
