IMPA2
Description
The IMPA2 (inositol monophosphatase 2) is a protein-coding gene located on chromosome 18.
IMPA2 is a 32 kDa enzyme encoded by the IMPA2 gene in humans. It dephosphorylates myo-inositol monophosphate to myo-inositol. IMPA2's function appears similar to IMPA1 within tissues, but the genes are expressed differently, with IMPA2 highly expressed in certain brain tissues and the kidney lumen. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.
IMPA2 utilizes a range of substrates including myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP. Research suggests it may be the target of lithium Li(+) action in the brain.
IMPA2 is also known as -.
Associated Diseases
- endometrial cancer
- nonpapillary renal cell carcinoma
- congenital hydronephrosis
- congenital primary megaureter
- bipolar disorder
- Ochoa syndrome
- renal hypoplasia
- renal dysplasia
- schizophrenia
