WDR1
Description
The WDR1 (WD repeat domain 1) is a protein-coding gene located on chromosome 4.
WDR1, encoded by the WDR1 gene, contains 9 WD repeats, which are protein-protein interaction domains. The protein may contribute to the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found.
WDR1 protein plays a role in actin filament disassembly, working in conjunction with ADF/cofilin family proteins. It enhances cofilin-mediated actin severing and is involved in cytokinesis. WDR1 restricts lamellipodial membrane protrusions during chemotactic cell migration, contributing to myocardium sarcomere organization and cardiomyocyte growth and maintenance. It is essential for megakaryocyte maturation and platelet shedding, and participates in the establishment of planar cell polarity (PCP) during follicular epithelium development. WDR1's function in PCP involves cooperation with CFL1 and/or DSTN/ADF, contributing to cell shape changes. It is also implicated in the generation/maintenance of cortical tension and in the assembly and maintenance of epithelial apical cell junctions, playing a role in the organization of the perijunctional actomyosin belt.
WDR1 is also known as AIP1, HEL-S-52, NORI-1, PFITS.
