TOP2B
Description
The TOP2B (DNA topoisomerase II beta) is a protein-coding gene located on chromosome 3.
TOP2B is a human gene that encodes DNA topoisomerase 2-beta, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA, allowing the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event: the beta form encoded by TOP2B on chromosome 3 and the alpha form on chromosome 17. TOP2B serves as a target for several anticancer agents, including mitoxantrone, and mutations in this gene have been linked to drug resistance. Reduced activity of TOP2B may also play a role in ataxia-telangiectasia. Alternative splicing of TOP2B results in two transcript variants, though the second variant is not fully characterized. During a new learning experience, a set of genes, including TOP2B, is rapidly expressed in the brain. This induced gene expression is considered essential for processing the information being learned.
TOP2B is also known as BILU, TOPIIB, top2beta.
Associated Diseases
- B-cell immunodeficiency, distal limb anomalies, and urogenital malformations
- adult acute lymphoblastic leukemia
- breast cancer
- lung cancer
- extranodal nasal NK/T cell lymphoma
- ovarian cancer
