TNFRSF1A

Description

The TNFRSF1A gene, located on chromosome 12, encodes the tumor necrosis factor receptor superfamily, member 1A (TNFR1). TNFR1 is a transmembrane protein that plays a crucial role in the immune system by binding to the cytokine tumor necrosis factor-alpha (TNF-alpha). This interaction triggers a signaling cascade that regulates various cellular processes, including inflammation, apoptosis, and cell survival. TNFR1 is involved in a wide range of physiological and pathological processes, and its dysregulation can contribute to the development of several diseases.

Associated Diseases

• Rheumatoid arthritis
• Crohn‘s disease
• Inflammatory bowel disease
• Multiple sclerosis
• Systemic lupus erythematosus
• Cancer
• Sepsis
• Neurodegenerative diseases

Did you know?

Mutations in the TNFRSF1A gene have been linked to a rare genetic disorder called TNF receptor-associated periodic syndrome (TRAPS), characterized by recurrent episodes of fever, inflammation, and pain.