TNFRSF1A
Description
The TNFRSF1A gene, located on chromosome 12, encodes the tumor necrosis factor receptor superfamily, member 1A (TNFR1). TNFR1 is a transmembrane protein that plays a crucial role in the immune system by binding to the cytokine tumor necrosis factor-alpha (TNF-alpha). This interaction triggers a signaling cascade that regulates various cellular processes, including inflammation, apoptosis, and cell survival. TNFR1 is involved in a wide range of physiological and pathological processes, and its dysregulation can contribute to the development of several diseases.
Associated Diseases
- Rheumatoid arthritis
- Crohn‘s disease
- Inflammatory bowel disease
- Multiple sclerosis
- Systemic lupus erythematosus
- Cancer
- Sepsis
- Neurodegenerative diseases
Did you know?
Mutations in the TNFRSF1A gene have been linked to a rare genetic disorder called TNF receptor-associated periodic syndrome (TRAPS), characterized by recurrent episodes of fever, inflammation, and pain.
