TERT
Description
The TERT gene, responsible for encoding the reverse transcriptase component of telomerase, plays a crucial role in maintaining the integrity of our chromosomes. Telomerase adds protective caps called telomeres to the ends of chromosomes, preventing them from degrading with each cell division. As we age, telomeres shorten, contributing to cellular senescence. However, TERT‘s role extends beyond aging, influencing various cellular processes, including proliferation, differentiation, and apoptosis.
Associated Diseases
- Cancer: Mutations in TERT can lead to increased telomerase activity, promoting uncontrolled cell growth and tumor development.
- Ataxia telangiectasia: A rare genetic disorder associated with impaired DNA repair mechanisms and telomere dysfunction.
- Dyskeratosis congenita: A disorder characterized by abnormal cell development and premature aging, often linked to TERT mutations.
Did you know?
Telomerase activity is typically low in most adult cells, but it is highly active in rapidly dividing cells like stem cells and germ cells.
