TCF3
Description
The TCF3 (transcription factor 3) is a protein-coding gene located on chromosome 19.
TCF3, also known as E2A, is a protein encoded by the TCF3 gene in humans. It belongs to the E protein family of transcription factors and plays a vital role in B and T lymphocyte development. TCF3 directly enhances Hes1 expression, a target of Notch signaling. TCF3 regulates developmental processes, including lymphocyte and central nervous system (CNS) development. Diminished TCF3 activity is linked to lymphoid malignancies, and the gene is involved in chromosomal translocations associated with various leukemias.
TCF3, also known as E2A, is a transcription factor that plays a crucial role in cell fate determination during development. It forms heterodimers with other bHLH proteins, influencing processes like neuronal differentiation and mesenchymal to epithelial transition. These heterodimers bind to specific DNA sequences called E-boxes, regulating gene expression in various tissues, including muscle and early B-cells. TCF3 is also essential for mesenchymal to epithelial transition in conjunction with TCF15. It directly binds to regulatory elements in the kappa immunoglobulin gene enhancer and the insulin gene transcription control region, influencing their expression.
TCF3 is also known as AGM8, AGM8A, AGM8B, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21, p75.
Associated Diseases
- Agammaglobulinemia 8B, autosomal recessive
- Agammaglobulinemia 8, autosomal dominant
- Autosomal agammaglobulinemia
